编码髓系α-3-岩藻糖基转移酶（FUT4）的基因位于11号染色体长臂21区（11q21）上的D11S388和D11S919之间。
The gene encoding myeloid alpha-3-fucosyl-transferase (FUT4) is located between D1 1S388 and D11S919 on 11q21.
作者信息
Reguigne I, James M R, Richard C W, Mollicone R, Seawright A, Lowe J B, Oriol R, Couillin P
机构信息
INSERM U178, Villejuif, France.
出版信息
Cytogenet Cell Genet. 1994;66(2):104-6. doi: 10.1159/000133677.
The last step in the biosynthesis of Le(x) antigen, the addition of a fucose to precursor polysaccharides, can be catalyzed by different alpha-3-fucosyltransferases. We localized the gene (FUT4) encoding myeloid alpha-3-fucosyltransferase by PCR assay using panels of somatic cell and radiation hybrids which retain different rearrangements of chromosome 11. FUT4 was assigned to chromosome band 11q21 between D11S388 and D11S919.
Le(x)抗原生物合成的最后一步，即在前体多糖上添加岩藻糖，可由不同的α-3-岩藻糖基转移酶催化。我们通过PCR分析，利用保留11号染色体不同重排的体细胞和辐射杂种细胞系，对编码髓系α-3-岩藻糖基转移酶的基因（FUT4）进行了定位。FUT4被定位于11号染色体带11q21，位于D11S388和D11S919之间。
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