将编码表皮丝氨酸蛋白酶抑制剂SKALP（PI3）的人类基因定位于染色体区域20q12→q13。
Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12-->q13.
作者信息
Molhuizen H O, Zeeuwen P L, Olde Weghuis D, Geurts van Kessel A, Schalkwijk J
机构信息
Department of Dermatology, University Hospital Nijmegen, The Netherlands.
出版信息
Cytogenet Cell Genet. 1994;66(2):129-31. doi: 10.1159/000133683.
Recently we isolated a cDNA clone corresponding to an epidermal serine proteinase inhibitor named SKALP (skin-derived antileukoproteinase). Here we report the chromosomal localization of the human gene encoding SKALP by Southern blot analysis of a panel of human x hamster hybrid cell lines and by nonradioactive in situ hybridization on R-banded human lymphocyte chromosome spreads. The SKALP-encoding gene has been assigned the approved symbol PI3 by the Human Gene Mapping nomenclature committee.
最近，我们分离出了一个与名为SKALP（皮肤源性抗白细胞蛋白酶）的表皮丝氨酸蛋白酶抑制剂相对应的cDNA克隆。在此，我们通过一组人×仓鼠杂交细胞系的Southern印迹分析以及在R带人类淋巴细胞染色体涂片上的非放射性原位杂交，报告了编码SKALP的人类基因的染色体定位。人类基因定位命名委员会已将编码SKALP的基因指定为认可符号PI3。
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