Young M P, Jones D R, Griffiths G J, Peeling W B, Roberts E E, Parkinson M C
Department of Histopathology, University College, London Medical School, UK.
Eur Urol. 1993;24(4):479-82. doi: 10.1159/000474354.
The histological and transrectal ultrasound (TRUS) appearances at corresponding sites of the periphery of the prostate gland have been compared in 30 benign and 27 malignant glands taken at autopsy. In the benign series, the histological capsule was frequently absent and correlated poorly with the consistent TRUS findings of a regular, well-defined 'ultrasonic capsule'. It is concluded that 'the capsule' should be replaced as a tumour-staging landmark by a more realistic terminology. Carcinoma may be described as intra- or extra-prostatic, or confined or unconfined with respect to the gland. In the malignant glands, there was no correlation between morphologically unconfined cancers and irregular or absent ultrasound 'capsule' when corresponding areas were compared. This disparity must contribute to an underestimation of tumour extent with TRUS.
对30例良性前列腺和27例恶性前列腺尸检标本前列腺外周相应部位的组织学表现和经直肠超声（TRUS）表现进行了比较。在良性组中，组织学包膜常常缺失，与TRUS所发现的规则、边界清晰的“超声包膜”的一致表现相关性较差。得出的结论是，“包膜”应被更实际的术语取代，作为肿瘤分期的标志。前列腺癌可描述为前列腺内或前列腺外，或相对于腺体局限或不局限。在恶性前列腺组中，当比较相应区域时，形态学上不局限的癌症与不规则或缺失的超声“包膜”之间没有相关性。这种差异必然导致TRUS对肿瘤范围的低估。
