Gao L, Zhou S, Wang J
Hua Xi Yi Ke Da Xue Xue Bao. 1993 Sep;24(3):328-30.
We made a comparative study of the cognitive function of 60 epileptic patients before and after the use of phenytoin (DPH) and carbamazepine (CBZ). Five types of neuropsychological tests were adopted. Although both DPH and CBZ affected cognitive function, the degrees of their effects were not the same. DPH affected cognitive function in a broad field, including concentration, remembrance, psychological motor speed and mental processing, whereas CBZ had only slight effect on perception and motor speed. It is stressed that cognitive function disorder caused by antiepileptic drugs should be early detected by synchronous examinations of the level of antiepileptic drugs and the neuropsychological functions.
我们对60例癫痫患者在使用苯妥英钠（DPH）和卡马西平（CBZ）前后的认知功能进行了对比研究。采用了五种神经心理学测试。虽然DPH和CBZ均会影响认知功能，但二者的影响程度不同。DPH在广泛领域影响认知功能，包括注意力、记忆力、心理运动速度和心理加工，而CBZ仅对感知和运动速度有轻微影响。强调应通过同步检测抗癫痫药物水平和神经心理功能来早期发现抗癫痫药物所致的认知功能障碍。
