Thompson P, Huppert F A, Trimble M
Br J Clin Psychol. 1981 Sep;20(3):155-62. doi: 10.1111/j.2044-8260.1981.tb00513.x.
Despite the widespread use of phenytoin in the treatment of epilepsy, few studies have examined its effects on cognitive functioning. We report here the results of an investigation into the effects of phenytoin on the performance of non-epileptic volunteers, on a series of specially designed psychological tests. Subjects received placebo or phenytoin 300 mg per day for two weeks in a double-blind crossover design and measures were taken of phenytoin serum levels. The results demonstrate a deleterious effect of phenytoin upon several important aspects of cognition, including memory, concentration, mental and motor speed. The implications of our findings for the treatment of patients with epilepsy are discussed.
尽管苯妥英钠在癫痫治疗中被广泛使用，但很少有研究考察其对认知功能的影响。我们在此报告一项针对苯妥英钠对非癫痫志愿者在一系列专门设计的心理测试中表现的影响的调查结果。在双盲交叉设计中，受试者接受安慰剂或每天300毫克苯妥英钠治疗，为期两周，并测定苯妥英钠的血清水平。结果表明，苯妥英钠对认知的几个重要方面有有害影响，包括记忆、注意力、思维和运动速度。我们讨论了研究结果对癫痫患者治疗的意义。
