Greco A, Mariani C, Miranda C, Pagliardini S, Pierotti M A
Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy.
Genomics. 1993 Nov;18(2):397-400. doi: 10.1006/geno.1993.1482.
TRK oncogenes are created by chromosomal rearrangements linking the tyrosine-kinase domain of the NTRK1 gene (encoding one of the receptors for the nerve growth factor) to foreign activating sequences. TRK oncogenes are frequently detected in human papillary thyroid carcinoma, as result of rearrangements involving at least three different activating genes. We have found that the rearrangements creating all the TRK oncogenes so far characterized fall within a 2.9-kb XbaI/SmaI restriction fragment of the NTRK1 gene. Here we report the nucleotide sequence and the exon organization of this fragment.
TRK癌基因是由染色体重排产生的，这些重排将NTRK1基因（编码神经生长因子的一种受体）的酪氨酸激酶结构域与外源激活序列连接起来。由于涉及至少三种不同激活基因的重排，TRK癌基因在人甲状腺乳头状癌中经常被检测到。我们发现，迄今为止所鉴定的所有产生TRK癌基因的重排都位于NTRK1基因的一个2.9 kb XbaI/SmaI限制性片段内。在此，我们报告该片段的核苷酸序列和外显子组织。
