de la Luz Orozco-Covarrubias M, Tamayo-Sanchez L, Duran-McKinster C, Ridaura C, Ruiz-Maldonado R
Department of Pediatric Dermatology, National Institute of Pediatrics, Mexico City, Mexico.
J Am Acad Dermatol. 1994 Feb;30(2 Pt 1):243-9.
The frequency of different malignant cutaneous tumors (MCTs), primary and metastatic, in children is not known. We reviewed all MCTs, primary and metastatic, seen during a 20-year period in a large general pediatric hospital. Fifty-three MCTs, 36 primary and 17 metastatic, were diagnosed in 36,207 pediatric dermatology patients. The incidence was 1.4 per 1000 patients. The relative frequency of occurrence of the different tumors was as follows: rhabdomyosarcoma, 25%; lymphomas, 19%; basal cell carcinoma, 13%; leukemia, 13%; neuroblastoma, 10%; malignant melanoma, 6%; squamous cell carcinoma, 6%; unclassified sarcomas, 4%; epithelioid schwannoma, 2%; ependymoma, 2%. The mean follow-up was 3 years; 48% died, 27% were lost to follow-up, and 25% are under control. We conclude that primary and metastatic MCTs in children are rare. Their types differ from MCTs in an older age population. MCTs in children are associated with a high mortality rate, often related to late recognition.
儿童原发性和转移性不同恶性皮肤肿瘤（MCTs）的发病率尚不清楚。我们回顾了一家大型综合儿科医院20年间诊治的所有原发性和转移性MCTs。在36207例儿科皮肤科患者中，共诊断出53例MCTs，其中36例为原发性，17例为转移性。发病率为每1000例患者中有1.4例。不同肿瘤的相对发生频率如下：横纹肌肉瘤，25%；淋巴瘤，19%；基底细胞癌，13%；白血病，13%；神经母细胞瘤，10%；恶性黑色素瘤，6%；鳞状细胞癌，6%；未分类肉瘤，4%；上皮样神经鞘瘤，2%；室管膜瘤，2%。平均随访时间为3年；48%的患者死亡，27%的患者失访，25%的患者病情得到控制。我们得出结论，儿童原发性和转移性MCTs很少见。它们的类型与老年人群中的MCTs不同。儿童MCTs与高死亡率相关，这通常与诊断延迟有关。
