Mukhtar H, Katiyar S K, Agarwal R
Department of Dermatology, University Hospitals of Cleveland, Case Western Reserve University, Ohio 44106.
J Invest Dermatol. 1994 Jan;102(1):3-7. doi: 10.1111/1523-1747.ep12371720.
Because of its special aroma, green tea is a popular beverage consumed by some human populations worldwide. In recent years, many laboratory studies have shown that in a variety of animal tumor bioassay systems the administration of green tea, specifically the polyphenolic fraction isolated from green tea leaves (green tea polyphenols), affords protection against cancer induction. In mouse skin tumor bioassay systems, topical application of green tea polyphenols to skin has been shown to result in protection against a) 3-methylcholanthrene-induced skin tumorigenicity, b) 7,12-dimethylbenz(a)anthracene (DMBA)-induced skin tumor initiation, c) 12-O-tetradecanoylphorbol-13-acetate and other tumor promoters caused tumor promotion in DMBA-initiated skin, and d) benzoyl peroxide- and 4-nitroquinoline N-oxide caused enhanced malignant progression of nonmalignant lesions. Green tea extract has also been shown to cause partial regression of established skin papillomas in mouse. Similarly, chronic oral feeding of green tea polyphenols or water extract of green tea has also been shown to result in the protection against both chemical carcinogen- and ultraviolet B radiation-induced skin tumorigenicity. Collectively these data suggest that green tea possesses significant chemopreventive effect against each stage of carcinogenesis, and that it may be useful against inflammatory responses associated with the exposure of skin to chemical tumor promoters as well as to solar radiation. Available data regarding the mechanism by which green tea affords these diversified effects is discussed.
由于其独特的香气，绿茶是全球一些人群喜爱饮用的饮品。近年来，许多实验室研究表明，在多种动物肿瘤生物测定系统中，给予绿茶，特别是从茶叶中分离出的多酚部分（绿茶多酚），可提供抗癌诱导保护作用。在小鼠皮肤肿瘤生物测定系统中，已表明将绿茶多酚局部应用于皮肤可导致对以下情况的保护作用：a）3 - 甲基胆蒽诱导的皮肤肿瘤发生，b）7,12 - 二甲基苯并(a)蒽（DMBA）诱导的皮肤肿瘤起始，c）12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯和其他肿瘤促进剂在DMBA起始的皮肤中引起的肿瘤促进，以及d）过氧化苯甲酰和4 - 硝基喹啉N - 氧化物引起的非恶性病变的恶性进展增强。绿茶提取物也已表明可使小鼠已形成的皮肤乳头瘤部分消退。同样，长期口服绿茶多酚或绿茶水提取物也已表明可对化学致癌物和紫外线B辐射诱导的皮肤肿瘤发生起到保护作用。总体而言，这些数据表明绿茶对致癌作用的各个阶段具有显著的化学预防作用，并且它可能对与皮肤接触化学肿瘤促进剂以及太阳辐射相关的炎症反应有用。讨论了关于绿茶产生这些多样化作用的机制的现有数据。
