Fedorcsák I, Sipos L, Horváth A, Kontra G, Bognár L, Osztie E
National Institute of Neurosurgery, Budapest, Hungary.
J Neurooncol. 1993 May;16(2):173-6. doi: 10.1007/BF01324705.
A case of malignant melanoma with multiplex brain metastases is described, where both surgical and radiosurgical treatment was applied. Due to CNS manifestations the patient was operated on in two sessions. First the symptomatic large tumor was removed, and the other, small lesion which could not be reached from the same approach was operated later. The primary skin lesion was discovered and removed between the two operations. A CT scan three months after the second operation revealed recurrence at the site of the first operation, and the appearance of two new tumors. The intracranial neoplasms were treated in one session by stereotactic radiosurgery using a linear accelerator. Six months after this treatment a new skin lesion was removed and the patient received DTIC therapy. Successive CT scans after the irradiation showed a steady regression of the radiosurgically treated tumors, and more than one year after the irradiation no tumor could be detected on the CT scans.
本文描述了一例伴有多发脑转移的恶性黑色素瘤病例，该病例同时接受了手术和放射外科治疗。由于中枢神经系统表现，患者分两次进行手术。首先切除有症状的大肿瘤，另一个无法通过相同入路触及的小病灶随后进行手术。在两次手术之间发现并切除了原发性皮肤病变。第二次手术后三个月的CT扫描显示第一次手术部位复发，并出现了两个新肿瘤。使用直线加速器通过立体定向放射外科在一次治疗中处理颅内肿瘤。该治疗六个月后切除了一个新的皮肤病变，患者接受了达卡巴嗪治疗。放疗后的连续CT扫描显示，接受放射外科治疗的肿瘤持续消退，放疗一年多后CT扫描未检测到肿瘤。
