Gray A B, Telford R D, Collins M, Weidemann M J
Faculty of Nursing and Health Sciences, Griffith University, Qld, Australia.
Med Sci Sports Exerc. 1993 Nov;25(11):1252-8.
Aerobic exercise has an established role in modulation of peripheral leukocyte concentrations. However, the effects of intense interval exercise, as employed by athletes in a range of sports, has been given little attention. Eight trained male athletes of mean age (SD) = 31.5 (4.5) yr; VO2max = 64.3 (3.8) ml.kg-1.min-1 undertook an intense interval exercise protocol (treadmill running) to exhaustion. Subjects completed an average of 15.6 1-min efforts. The protocol produced a biphasic leukocytosis: an initial (immediately posttest) leukocytosis resulting from mobilization of lymphocytes (CD3+, CD4+, CD8+, CD16+/56+, CD3+HLA/DR+) (all P < 0.01), with the later (6 h) leukocytosis resulting from mobilization of granulocytes and monocytes (both P < 0.01). This protocol modified significantly the peripheral blood concentration of the hormones cortisol (both total and free), norepinephrine, DHPG, and dopamine (all P < 0.01). Modulation of peripheral leukocyte subsets induced by interval exercise correlated with both the number of exercise efforts performed and the concomitant changes in peripheral hormone concentrations. Sustained alterations in plasma catecholamine levels in the posttest period may have important metabolic and immunological implications for athletes undertaking regular interval training.
有氧运动在调节外周血白细胞浓度方面具有确定的作用。然而，运动员在一系列运动中所采用的高强度间歇运动的影响却很少受到关注。八名训练有素的男性运动员，平均年龄（标准差）= 31.5（4.5）岁；最大摄氧量= 64.3（3.8）毫升·千克⁻¹·分钟⁻¹，进行了一项高强度间歇运动方案（跑步机跑步）直至力竭。受试者平均完成了15.6次1分钟的运动。该方案产生了双相白细胞增多：最初（运动后即刻）的白细胞增多是由淋巴细胞（CD3⁺、CD4⁺、CD8⁺、CD16⁺/56⁺、CD3⁺HLA/DR⁺）动员所致（所有P < 0.01），而后期（6小时）的白细胞增多是由粒细胞和单核细胞动员所致（两者P < 0.01）。该方案显著改变了皮质醇（总皮质醇和游离皮质醇）、去甲肾上腺素、二氢孕酮和多巴胺等激素的外周血浓度（所有P < 0.01）。间歇运动诱导的外周血白细胞亚群的调节与运动次数以及外周血激素浓度的相应变化相关。运动后阶段血浆儿茶酚胺水平的持续改变可能对进行定期间歇训练的运动员具有重要的代谢和免疫意义。
