Malmros C, Blomquist S, Mårtensson L, Thörne J
Department of Anesthesiology and Surgery, University Hospital Lund, Sweden.
Nephron. 1993;65(3):449-53. doi: 10.1159/000187528.
We have previously documented that neutrophils (polymorphonuclear leukocytes) aggregate in the lungs 10-15 min after the start of dialysis. The aim of the present study was to investigate the corresponding platelet reaction and evaluate the effect of prewarmed priming solution on this reaction. The animals were divided into two groups, each consisting of 6 pigs. In group 1 the priming solution was prewarmed to 36-38 degrees C whereas it was maintained at room temperature in group 2. Platelets were selectively labelled with 111In-oxine. The activity over the lung was followed dynamically with a gamma camera and already after 2 min a significant difference in platelet sequestration showed between the groups. A significant increase in pulmonary vascular resistance was noted in group 2, but not in group 1. In conclusion, platelet aggregation occurs early on during dialysis in this model. The results also indicate that prewarming the priming solution attenuates the pulmonary platelet sequestration and also seems to decrease the changes in central hemodynamics.
我们之前已记录到，透析开始后10 - 15分钟，中性粒细胞（多形核白细胞）会在肺部聚集。本研究的目的是调查相应的血小板反应，并评估预温的预充液对该反应的影响。将动物分为两组，每组6头猪。第1组的预充液预温至36 - 38摄氏度，而第2组则维持在室温。用111铟 - 奥克辛选择性标记血小板。用γ相机动态跟踪肺部的活性，2分钟后两组之间的血小板滞留就显示出显著差异。第2组出现肺血管阻力显著增加，而第1组未出现。总之，在该模型中，透析过程中早期就会发生血小板聚集。结果还表明，预温预充液可减轻肺部血小板滞留，并且似乎还能减少中心血流动力学的变化。
