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借助抗氧化剂纠正猴子视觉识别障碍

Correction of a disturbance in visual recognition in monkeys with the aid of an antioxidant.

作者信息

Dudkin K N, Kruchinin V K, Chueva I V

机构信息

Laboratory of the Regulation of the Functions of Brain Neurons, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg.

出版信息

Neurosci Behav Physiol. 1993 Nov-Dec;23(6):557-61. doi: 10.1007/BF01153684.

Abstract

The influence of an effective antioxidant, oxymethacil, was studied in a model of the disruption of visual recognition induced by the antidepressant fluoracyzine. The normal discrimination of black and white visual stimuli in monkeys is restored with the systemic administration of oxymethacil in a dose of 3 mg/kg following disruption brought about by the effect of fluoracyzine. The discrimination of colored visual stimuli, as in the norm, is restored following the systemic administration of oxymethacil in a dose of 4 mg/kg. The results obtained attest to the corrective properties of oxymethacil.

摘要

在抗抑郁药氟西嗪诱导的视觉识别障碍模型中,研究了一种有效的抗氧化剂奥昔美辛的影响。在氟西嗪作用导致破坏后,以3mg/kg的剂量全身给予奥昔美辛,可恢复猴子对黑白视觉刺激的正常辨别能力。以4mg/kg的剂量全身给予奥昔美辛后,对彩色视觉刺激的辨别能力如正常情况一样恢复。所获得的结果证明了奥昔美辛的矫正特性。

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