先兆子痫患者低钙尿症的病理生理学：肠道钙吸收的测量

Pathophysiology of hypocalciuria in preeclampsia: measurement of intestinal calcium absorption.

作者信息

Tolaymat A, Sanchez-Ramos L, Yergey A L, Vieira N E, Abrams S A, Edelstein P

机构信息

Department of Pediatrics, University of Florida Health Science Center/Jacksonville.

出版信息

Obstet Gynecol. 1994 Feb;83(2):239-43.

PMID:8290187

Abstract

OBJECTIVE

To analyze calcium absorption using stable isotopes in patients with preeclampsia and in normotensive controls.

METHODS

Fifteen pregnant subjects were studied: eight with preeclampsia (hypertension and proteinuria) and seven normotensive controls. All patients were ingesting their normal diet. The subjects received two stable calcium isotopic tracers. An oral tracer (44Ca, 0.0124 mmol/kg) was given with milk, while an intravenous tracer (42Ca, 0.00249 mmol/kg) was infused over 7-10 minutes. Calcium concentration was determined by atomic absorption spectrophotometry, and isotope ratios by thermal ionization mass spectrometry from pooled 24-hour urine samples.

RESULTS

No difference was noted in fractional intestinal absorption between preeclamptic subjects (0.282 +/- 0.051) and normotensive controls (0.306 +/- 0.079) (P = .49). However, the fraction of dietary calcium appearing in the urine differed significantly (0.06 for preeclamptic subjects and 0.087 for normotensive controls; P = .008).

CONCLUSIONS

Despite the indirect evidence of others, calcium absorption does not appear to be impaired in patients with preeclampsia. The retention site of the unexcreted calcium is unidentified.

摘要

目的

采用稳定同位素分析子痫前期患者和血压正常对照组的钙吸收情况。

方法

对15名孕妇进行了研究：8名单纯收缩期高血压患者（高血压和蛋白尿）和7名血压正常的对照者。所有患者均正常饮食。受试者接受了两种稳定的钙同位素示踪剂。口服示踪剂（44Ca，0.0124 mmol/kg）与牛奶一起服用，而静脉示踪剂（42Ca，0.00249 mmol/kg）在7 - 10分钟内输注完毕。通过原子吸收分光光度法测定钙浓度，通过热电离质谱法测定来自24小时混合尿液样本的同位素比率。