Tolaymat A, Sanchez-Ramos L, Yergey A L, Vieira N E, Abrams S A, Edelstein P
Department of Pediatrics, University of Florida Health Science Center/Jacksonville.
Obstet Gynecol. 1994 Feb;83(2):239-43.
To analyze calcium absorption using stable isotopes in patients with preeclampsia and in normotensive controls.
Fifteen pregnant subjects were studied: eight with preeclampsia (hypertension and proteinuria) and seven normotensive controls. All patients were ingesting their normal diet. The subjects received two stable calcium isotopic tracers. An oral tracer (44Ca, 0.0124 mmol/kg) was given with milk, while an intravenous tracer (42Ca, 0.00249 mmol/kg) was infused over 7-10 minutes. Calcium concentration was determined by atomic absorption spectrophotometry, and isotope ratios by thermal ionization mass spectrometry from pooled 24-hour urine samples.
No difference was noted in fractional intestinal absorption between preeclamptic subjects (0.282 +/- 0.051) and normotensive controls (0.306 +/- 0.079) (P = .49). However, the fraction of dietary calcium appearing in the urine differed significantly (0.06 for preeclamptic subjects and 0.087 for normotensive controls; P = .008).
Despite the indirect evidence of others, calcium absorption does not appear to be impaired in patients with preeclampsia. The retention site of the unexcreted calcium is unidentified.
采用稳定同位素分析子痫前期患者和血压正常对照组的钙吸收情况。
对15名孕妇进行了研究：8名单纯收缩期高血压患者（高血压和蛋白尿）和7名血压正常的对照者。所有患者均正常饮食。受试者接受了两种稳定的钙同位素示踪剂。口服示踪剂（44Ca，0.0124 mmol/kg）与牛奶一起服用，而静脉示踪剂（42Ca，0.00249 mmol/kg）在7 - 10分钟内输注完毕。通过原子吸收分光光度法测定钙浓度，通过热电离质谱法测定来自24小时混合尿液样本的同位素比率。
子痫前期患者（0.282±0.051）和血压正常对照组（0.306±0.079）之间的小肠吸收分数无差异（P = 0.49）。然而，尿中膳食钙的分数有显著差异（子痫前期患者为0.06，血压正常对照组为0.087；P = 0.008）。
尽管有其他间接证据，但子痫前期患者的钙吸收似乎并未受损。未排泄钙的潴留部位尚不清楚。
