Ozcan T, Kaleli B, Ozeren M, Turan C, Zorlu G
Dr. Zekai Tahir Burak Maternity Hospital, Ankara, Turkey.
Am J Perinatol. 1995 Sep;12(5):349-51. doi: 10.1055/s-2007-994494.
Urinary calcium excretion decreases in preeclampsia. To determine the predictability of preeclampsia with hypocalciuria, we investigated the calcium to creatinine ratio and the calcium level of a spot urine sample in 56 primigravid patients aged less than 25 years. Of these 56 cases, 44 remained normotensive and preeclampsia developed in eight cases. There were four cases of gestational hypertension and they are not included in the statistical analysis. The mean age, the mean gestational age at entrance into the study, the mean urine calcium concentration, the mean birthweight, and the mean gestational age at delivery were similar between the normotensive and preeclamptic groups. The mean calcium to creatinine ratio is found to be significantly lower in the preeclamptic group (0.0475 +/- 0.0260) compared with the normotensive group (0.1466 +/- 0.1353; p < 0.0001). A cutoff level of 0.066 for the calcium to creatinine ratio with the use of a receiver operator curve yielded a sensitivity of 75%, a specificity of 86%, and a positive and negative predictive value of 55% and 95%, respectively. The results of this study suggest that a single urine calcium to creatinine ratio might be an effective marker for predicting preeclampsia in a high-risk population.
子痫前期患者尿钙排泄减少。为了确定低钙尿症对子痫前期的预测价值，我们对56名年龄小于25岁的初产妇进行了研究，检测了其随机尿样中的钙肌酐比值和钙水平。这56例患者中，44例血压正常，8例发生子痫前期。有4例妊娠期高血压，未纳入统计分析。血压正常组和子痫前期组在平均年龄、进入研究时的平均孕周、平均尿钙浓度、平均出生体重以及分娩时的平均孕周方面相似。子痫前期组的平均钙肌酐比值（0.0475±0.0260）显著低于血压正常组（0.1466±0.1353；p<0.0001）。利用受试者工作特征曲线得出钙肌酐比值的截断值为0.066时，敏感性为75%，特异性为86%，阳性预测值和阴性预测值分别为55%和95%。本研究结果提示，单次尿钙肌酐比值可能是预测高危人群子痫前期的有效指标。
