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使用稳定同位素进行一日测试以测量真实的钙吸收分数。

One-day test using stable isotopes to measure true fractional calcium absorption.

作者信息

Eastell R, Vieira N E, Yergey A L, Riggs B L

机构信息

Division of Endocrinology, Metabolism and Internal Medicine, Mayo Clinic, Rochester, MN.

出版信息

J Bone Miner Res. 1989 Aug;4(4):463-8. doi: 10.1002/jbmr.5650040403.

DOI:10.1002/jbmr.5650040403
PMID:2816495
Abstract

True calcium absorption can only be measured by the time-consuming and expensive metabolic balance method and is not predicted well by measuring the fractional absorption (FA) of radiocalcium from a fixed calcium carrier. We describe here a 1 day method for measuring the actual fraction of calcium absorbed from the habitual diet (true fractional calcium absorption, TFCA) using stable isotopes of calcium. Oral and intravenous isotopes were administered with each of the three daily meals, and then the ratio of the two isotopes in the urine was measured by mass spectroscopy. In 12 subjects, TFCA determined from stable Ca correlated well with TFCA measured by the balance method (r = 0.71, P less than 0.01), and the mean values were not different (0.26 and 0.26). In contrast, no significant correlation was found between FA and TFCA. The weak relationship between FA and TFCA underscores the importance of tracing dietary calcium rather than a fixed calcium carrier in tests of calcium absorption. Using the new method, TFCA was inversely related to dietary calcium (r = -0.45, P less than 0.05), demonstrating that it could detect physiological changes in calcium absorption. Thus, this test has two important advantages: (1) it provides a simple way to measure TFCA and true fractional calcium absorption (the product of TFCA and dietary calcium), the physiologically relevant variables, and (2) because there is no radiation exposure, the test can be used in pregnant women and children, the isotopes can be prepared in advance, and several isotopes can be used simultaneously.

摘要

真正的钙吸收只能通过耗时且昂贵的代谢平衡法来测定,而通过测量放射性钙从固定钙载体中的分数吸收(FA)并不能很好地预测。我们在此描述一种使用钙的稳定同位素来测量从日常饮食中吸收的钙的实际分数(真正的分数钙吸收,TFCA)的1天方法。口服和静脉注射的同位素与每日三餐一起给予,然后通过质谱法测量尿液中两种同位素的比率。在12名受试者中,由稳定钙测定的TFCA与通过平衡法测量的TFCA相关性良好(r = 0.71,P小于0.01),且平均值无差异(0.26和0.26)。相比之下,未发现FA与TFCA之间存在显著相关性。FA与TFCA之间的弱关系强调了在钙吸收测试中追踪膳食钙而非固定钙载体的重要性。使用新方法,TFCA与膳食钙呈负相关(r = -0.45,P小于0.05),表明它可以检测钙吸收的生理变化。因此,该测试有两个重要优点:(1)它提供了一种简单的方法来测量TFCA和真正的分数钙吸收(TFCA与膳食钙的乘积),这两个是生理相关变量;(2)由于无辐射暴露,该测试可用于孕妇和儿童,同位素可提前制备,并且可以同时使用几种同位素。

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