Sassani J W, Ritch R, McCormick S, Liebmann J M, Eagle R C, Lavery K, Koster H R
Department of Ophthalmology, Penn State University College of Medicine, Hershey 17033.
Ophthalmic Surg. 1993 Nov;24(11):740-5.
We report the light and electron microscopic findings from two eyes treated with argon laser peripheral iridoplasty (ALPI) for bilateral angle-closure glaucoma. The patient, a 45-year-old man, died from complications of acquired immunodeficiency syndrome 16 days following ALPI. Ocular pathologic findings included contraction furrow formation and proliferation of fibroblast-like cells, accompanied by collagen deposition on the iris surface, denaturation of stromal collagen, and coagulative necrosis of blood vessels within the anterior two thirds of the iris stroma. These findings suggest that heat shrinkage of collagen may be responsible for the short-term response to ALPI, and that contraction of the fibroblastic membrane may be responsible for its long-term effects. Additionally, the presence of coagulative necrosis of iris blood vessels suggests that overt treatment may result in iris necrosis. To our knowledge this is the first report of the histopathology of ALPI.
我们报告了两例接受氩激光周边虹膜成形术（ALPI）治疗双侧闭角型青光眼的眼部光镜和电镜检查结果。患者为一名45岁男性，在接受ALPI治疗16天后死于获得性免疫缺陷综合征并发症。眼部病理检查结果包括收缩沟形成和成纤维细胞样细胞增殖，伴有虹膜表面胶原沉积、基质胶原变性以及虹膜基质前三分之二内血管的凝固性坏死。这些结果表明，胶原的热收缩可能是ALPI短期反应的原因，而成纤维细胞膜的收缩可能是其长期效果的原因。此外，虹膜血管凝固性坏死的存在表明过度治疗可能导致虹膜坏死。据我们所知，这是关于ALPI组织病理学的首次报告。
