恶性疟原虫染色体的多态性亚端粒区域包含重复序列元件阵列。
The polymorphic subtelomeric regions of Plasmodium falciparum chromosomes contain arrays of repetitive sequence elements.
作者信息
de Bruin D, Lanzer M, Ravetch J V
机构信息
DeWitt Wallace Research Laboratory, Division of Molecular Biology, Sloan-Kettering Institute, New York, NY 10021.
出版信息
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):619-23. doi: 10.1073/pnas.91.2.619.
The human malaria parasite Plasmodium falciparum exhibits a high degree of chromosomal polymorphism, which may contribute to its ability to evade host defenses. The analysis of parasite chromosomes has revealed that these polymorphisms are confined to the subtelomeric regions, which are transcriptionally silent and contain repetitive sequence elements. Several subtelomeric repetitive elements have been isolated and mapped by using P. falciparum yeast artificial chromosome (YAC) clones. Structural analysis of parasite telomeric and subtelomeric YAC clones demonstrated that these repetitive elements are conserved between P. falciparum chromosome ends. We suggest that these subtelomeric elements promote chromosome pairing in P. falciparum and facilitate meiotic recombination and gene conversion between telomere-proximal genes.
人类疟原虫恶性疟原虫表现出高度的染色体多态性，这可能有助于其逃避宿主防御的能力。对疟原虫染色体的分析表明，这些多态性局限于亚端粒区域，该区域转录沉默且含有重复序列元件。通过使用恶性疟原虫酵母人工染色体（YAC）克隆，已分离并定位了几个亚端粒重复元件。对疟原虫端粒和亚端粒YAC克隆的结构分析表明，这些重复元件在恶性疟原虫染色体末端之间是保守的。我们认为，这些亚端粒元件促进了恶性疟原虫中的染色体配对，并促进了端粒近端基因之间的减数分裂重组和基因转换。
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