Pastor A M, De la Cruz R R, Baker R
Department of Physiology and Biology, University of Seville, Spain.
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):807-11. doi: 10.1073/pnas.91.2.807.
Two types of central nervous system integrators are critical for oculomotor performance. The first integrates velocity commands to create position signals that hold fixation of the eye. The second stores relative velocity of the head and visual surround to stabilize gaze both during and after the occurrence of continuous self and world motion. We have used recordings from single neurons to establish that the "position" and "velocity" integrators for horizontal eye movement occupy adjacent, but nonoverlapping, locations in the goldfish medulla. Lidocaine inactivation of each integrator results in the eye movement deficits expected if horizontal eye position and velocity signals are processed separately. These observations also indicate that each brainstem compartment generates and stores these signals. Consequently, each integrator exhibits functional autonomy. Therefore, we propose that the intrinsic electrophysiological properties of the constituent neurons in each brainstem subnucleus may be sufficient for producing integrator rhythmicity.
两种类型的中枢神经系统整合器对眼球运动表现至关重要。第一种整合速度指令以创建保持眼睛注视的位置信号。第二种存储头部和视觉环境的相对速度，以便在持续的自我和世界运动期间及之后稳定注视。我们利用单个神经元的记录确定，金鱼延髓中水平眼球运动的“位置”和“速度”整合器占据相邻但不重叠的位置。利多卡因对每个整合器的失活会导致预期的眼球运动缺陷，前提是水平眼球位置和速度信号是分开处理的。这些观察结果还表明，每个脑干区室都会产生并存储这些信号。因此，每个整合器都表现出功能自主性。所以，我们提出每个脑干亚核中组成神经元的内在电生理特性可能足以产生整合器节律。
