Altmann M, Trachsel H
Institute of Biochemistry and Molecular Biology, University of Berne, Switzerland.
Trends Biochem Sci. 1993 Nov;18(11):429-32. doi: 10.1016/0968-0004(93)90143-b.
Translational control of gene expression is an important regulatory mechanism in cellular physiology. In eukaryotes, ribosomes can initiate translation by two different mechanisms: a majority of mRNAs undergo cap-dependent initiation at their extreme 5'-ends, but initiation can occur internally in some mRNAs. A number of important cellular responses, such as entry into a proliferative state and adaptation to changing nutrient levels, are mediated by changes in the mechanism of translation initiation of specific mRNAs. This article discusses new insights into control of gene expression gained through studies of regulation of eukaryotic translational initiation.
基因表达的翻译调控是细胞生理学中的一种重要调控机制。在真核生物中，核糖体可以通过两种不同机制起始翻译：大多数mRNA在其5'端的极端位置进行帽依赖性起始，但在某些mRNA中起始可在内部发生。许多重要的细胞反应，如进入增殖状态和适应营养水平变化，是由特定mRNA翻译起始机制的变化介导的。本文讨论了通过对真核生物翻译起始调控的研究获得的关于基因表达调控的新见解。
