Condom E, Vidal A, Rota R, Graus F, Dalmau J, Ferrer I
Servicio Anatomía Patológica, Hospital Príncipes de España, Hospitalet de Llobregat, Spain.
Virchows Arch A Pathol Anat Histopathol. 1993;423(6):507-11. doi: 10.1007/BF01606543.
Anti-Hu autoantibodies in high titres, as revealed with immunocytochemistry and Western blot, were present in a patient with gastrointestinal pseudo-obstruction and small-cell lung cancer (SCLC) bearing the Hu antigen. Marked neuron and nerve fibre loss were found in the myenteric plexus at postmortem. These findings show that neuronopathic Hu-associated gastrointestinal pseudo-obstruction can occur as the only paraneoplastic neurological symptom in patients with SCLC.
免疫细胞化学和蛋白质印迹显示，一名患有胃肠道假性梗阻和携带Hu抗原的小细胞肺癌（SCLC）患者体内存在高滴度的抗Hu自身抗体。尸检时发现肌间神经丛有明显的神经元和神经纤维丢失。这些发现表明，神经元病性Hu相关胃肠道假性梗阻可作为SCLC患者唯一的副肿瘤性神经症状出现。
