Chapman D B, James A M
Microbios. 1976;16(64):111-23.
The surface properties of cells of Pseudomonas aeruginosa which are sensitive to gentamicin are markedly different from those which are resistant to gentamicin. Cells of four out of five strains in which gentamicin-resistance is R-factor-mediated have electrokinetic properties characteristic of gentamicin-sensitive cells. The surface properties of transconjugant strains are indistinguishable from those of the original acceptor strain. Cells of the remaining R-factor donor strain (which transferred very low gentamicin-resistance) exhibited surface properties characteristic of gentamicin-resistant cells. Gentamicin-resistance in cells of this strain is thus the result of at least two different mechanisms. The results are discussed in terms of possible alternative mechanisms of resistance.
对庆大霉素敏感的铜绿假单胞菌细胞的表面特性与对庆大霉素耐药的细胞明显不同。五株中四株的庆大霉素耐药性由R因子介导，其细胞具有庆大霉素敏感细胞的电动特性。转接合子菌株的表面特性与原始受体菌株无法区分。其余的R因子供体菌株（其传递的庆大霉素耐药性非常低）的细胞表现出庆大霉素耐药细胞的表面特性。因此，该菌株细胞中的庆大霉素耐药性是至少两种不同机制的结果。根据可能的替代耐药机制对结果进行了讨论。
