Horiuchi A, Abe Y, Miyake M, Kimura K, Osuka Y, Kimura S
Second Department of Surgery, Ehime University School of Medicine, Japan.
Surg Today. 1993;23(11):964-8. doi: 10.1007/BF00308971.
Membrane-associated lymphotoxin (mLT) is induced in human peripheral blood mononuclear cells when cultured with interleukin 2, in the form of lymphokine-activated killer (LAK) cells. The inductivity of mLT is thought to be dependent upon the differentiation potential of LAK cell precursors, being T cells and natural killer cells. In this study, we investigated the inductivity of mLT on LAK cells from surgical patients. The preoperative values of mLT inductivity were found to be generally higher in malignant than benign cases, and the postoperative time course of mLT inductivity showed a transient decrease immediately after the operation followed by gradual increase over 2 weeks. Moreover, patients with an intraoperative bleeding volume of more than 1,000 ml showed a delay in the postoperative increase of mLT inductivity. These data suggest that operative stress potentiates the inductivity of mLT on LAK cells; however, excess stress may cause a delay in the restoration of mLT inductivity.
膜相关淋巴毒素（mLT）在人外周血单个核细胞与白细胞介素2一起培养时，以淋巴因子激活的杀伤细胞（LAK细胞）的形式被诱导产生。mLT的诱导性被认为取决于LAK细胞前体（即T细胞和自然杀伤细胞）的分化潜能。在本研究中，我们调查了mLT对手术患者LAK细胞的诱导性。发现恶性病例中mLT诱导性的术前值通常高于良性病例，并且mLT诱导性的术后时间进程显示术后立即出现短暂下降，随后在2周内逐渐增加。此外，术中出血量超过1000 ml的患者术后mLT诱导性增加出现延迟。这些数据表明手术应激增强了mLT对LAK细胞的诱导性；然而，过度应激可能导致mLT诱导性恢复延迟。
