Shibasaki H, Sadato N, Lyshkow H, Yonekura Y, Honda M, Nagamine T, Suwazono S, Magata Y, Ikeda A, Miyazaki M
Department of Brain Pathophysiology, Kyoto University School of Medicine, Japan.
Brain. 1993 Dec;116 ( Pt 6):1387-98. doi: 10.1093/brain/116.6.1387.
In order to clarify the roles played by the primary motor cortex and the supplementary motor area in the execution of complex sequential and simple repetitive finger movements, regional cerebral blood flow (rCBF) was measured with PET using 15O-labelled water in five normal subjects. The PET data of each individual subject co-registered to his own MRI, was analysed. Compared with the resting condition, the mean rCBF was markedly increased in the contralateral sensorimotor cortex (M1-S1) and moderately increased in the contralateral cingulate gyrus and putamen in both the simple and complex motor tasks. During the complex motor task, in addition to the above, the mean rCBF was markedly increased in the supplementary motor area and the contralateral premotor area, and moderately increased in the ipsilateral M1-S1 and cerebellum. In the supplementary motor area, there was a moderate rCBF increase also during the simple task. However, comparison of the mean rCBF increase against the resting condition between the two tasks revealed a greater increase during the complex task than in the other only in the supplementary motor area and the ipsilateral M1-S1. Thus, in agreement with our previous electrophysiological findings, not only the supplementary motor area but also the M1-S1 seems to play an important role in the execution of complex sequential finger movements.
为了阐明初级运动皮层和辅助运动区在执行复杂的连续和简单重复手指运动中所起的作用，使用15O标记的水通过正电子发射断层扫描（PET）对5名正常受试者的局部脑血流量（rCBF）进行了测量。分析了每个受试者与自身磁共振成像（MRI）配准的PET数据。与静息状态相比，在简单和复杂运动任务中，对侧感觉运动皮层（M1-S1）的平均rCBF显著增加，对侧扣带回和壳核的平均rCBF中度增加。在复杂运动任务期间，除上述情况外，辅助运动区和对侧运动前区的平均rCBF显著增加，同侧M1-S1和小脑的平均rCBF中度增加。在简单任务期间，辅助运动区的rCBF也有中度增加。然而，比较两个任务中相对于静息状态的平均rCBF增加情况，发现仅在辅助运动区和同侧M1-S1中，复杂任务期间的增加幅度大于简单任务。因此，与我们之前的电生理研究结果一致，不仅辅助运动区，而且M1-S1似乎在复杂的连续手指运动执行中发挥重要作用。
