Sabatini U, Chollet F, Rascol O, Celsis P, Rascol A, Lenzi G L, Marc-Vergnes J P
INSERM U230, Toulouse, France.
J Cereb Blood Flow Metab. 1993 Jul;13(4):639-45. doi: 10.1038/jcbfm.1993.82.
We measured, using single photon emission computed tomography, the regional CBF (rCBF) changes in the motor areas of 24 right-handed normal volunteers during the performance of a motor task consisting of sequential finger-to-thumb opposition. Twelve of them performed the task with their right and their left hands consecutively with a fast frequency and large amplitude. The other 12 subjects performed the task with their right hand only at a slow frequency and small amplitude. The contralateral primary sensorimotor areas (S1/M1), supplementary motor area (SMA), and ipsilateral cerebellum were significantly activated during right and left finger movements performed at fast frequency and large amplitude. No significant difference was found between the rCBF changes induced by the right dominant and left nondominant hands. When the task was performed with a slow rate and small amplitude, the SMA was significantly activated while no significant changes were observed in the contralateral S1/M1 or in the ipsilateral cerebellum. These results demonstrate (a) that hand dominance evokes no differences in the activation of the main motor areas and (b) that the frequency and amplitude of the movement have a major effect on the quantitative and qualitative aspect of activation of motor areas in humans.
我们使用单光子发射计算机断层扫描技术，测量了24名右利手正常志愿者在执行一项由手指向拇指连续对指组成的运动任务期间，其运动区域的局部脑血流量（rCBF）变化。其中12名志愿者以快速频率和大幅度连续用右手和左手执行该任务。另外12名受试者仅以慢速频率和小幅度用右手执行该任务。在以快速频率和大幅度进行右手和左手手指运动期间，对侧初级感觉运动区（S1/M1）、辅助运动区（SMA）和同侧小脑均被显著激活。右优势手和左非优势手引起的rCBF变化之间未发现显著差异。当以慢速频率和小幅度执行任务时，SMA被显著激活，而对侧S1/M1或同侧小脑未观察到显著变化。这些结果表明：（a）手的优势在主要运动区域的激活方面不会引起差异；（b）运动的频率和幅度对人类运动区域激活的数量和质量方面有重大影响。
