Guo Y, Zhou L
Institute of Urology, Beijing Medical University.
Zhonghua Yi Xue Za Zhi. 1993 Jul;73(7):420-3, 448.
We observed the effect of high energy shock waves (HESW) on tumor growth, histological and ultrastructural variations, and metastasis to lymph nodes and viscera in nude mice with implanted tumors. HESW was cytotoxic to tumors in vivo, and acted on levels of cell membrane, cytoplasmic organelles, and nuclear chromatins. At definite working voltage, this effect was positively proportional to the impulse number. Histological examination showed no metastatic focci to lymph nodes and viscera of nude mice with implanted tumors. The possible mechanism of HESW in vivo may be direct mechanical damage and indirect inhibition of tumor growth due to damage to the blood supply. Other hypotheses were also discussed.
我们观察了高能冲击波（HESW）对荷瘤裸鼠肿瘤生长、组织学和超微结构变化以及向淋巴结和内脏转移的影响。HESW在体内对肿瘤具有细胞毒性，作用于细胞膜、细胞质细胞器和核染色质水平。在一定工作电压下，这种作用与脉冲数成正比。组织学检查显示，荷瘤裸鼠的淋巴结和内脏未出现转移灶。HESW在体内的可能机制可能是直接机械损伤以及由于对血液供应的损伤而间接抑制肿瘤生长。还讨论了其他假说。
