Chen C L, Guo Z H, Zhao Y, Yan C Y, Pu J X, Chen Z X, Zhang R
Department of Urology, First Affiliated Hospital, Suzhou Medical College.
Chin Med J (Engl). 1991 Jul;104(7):548-51.
Suppressive effect on tumor cells of high energy shock waves (HESW) has aroused the interest of physicians in recent years. We assessed experimentally the cytotoxic effects of HESW on tumor cells both in vitro and in vivo and determined whether a Chinese domestic lithotriptor is capable of generating effective HESW, which has the potential to break tumor cells, reduce cell viability, retard cell growth, delay doubling time, impair cell attachment and cell clonogenicity. In nude rats, HESW was able to delay tumor growth and reduce tumor size without evidence of metastasis. The nature of HESW in the induction of cell damage and its clinical application need to be further investigated.
近年来，高能冲击波（HESW）对肿瘤细胞的抑制作用引起了医生们的关注。我们通过实验评估了HESW在体外和体内对肿瘤细胞的细胞毒性作用，并确定了国产碎石机是否能够产生有效的HESW，这种冲击波有可能破坏肿瘤细胞、降低细胞活力、抑制细胞生长、延长倍增时间、损害细胞黏附和细胞克隆形成能力。在裸鼠体内，HESW能够延缓肿瘤生长并减小肿瘤大小，且无转移迹象。HESW诱导细胞损伤的本质及其临床应用仍需进一步研究。
