Connolly J M, Rose D P
Division of Nutrition and Endocrinology, American Health Foundation, Valhalla, NY 10595.
Cancer Lett. 1993 Dec 10;75(2):137-42. doi: 10.1016/0304-3835(93)90198-i.
An in vitro invasion assay system was used to examine the effects of linoleic acid, an omega-6 fatty acid, and two omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid, on the invasive capacity of MDA-MB-435 human breast cancer cells. Linoleic acid stimulated, and the omega-3 fatty acids inhibited, tumor cell invasion at concentrations of 0.25 and 0.5 microgram/ml. Indomethacin, 20 micrograms/ml, completely suppressed the stimulatory activity of linoleic acid, suggesting that these fatty acid effects are mediated via eicosanoid biosynthesis.
采用体外侵袭试验系统，研究了ω-6脂肪酸亚油酸以及两种ω-3脂肪酸二十碳五烯酸和二十二碳六烯酸对MDA-MB-435人乳腺癌细胞侵袭能力的影响。在浓度为0.25和0.5微克/毫升时，亚油酸刺激肿瘤细胞侵袭，而ω-3脂肪酸则抑制肿瘤细胞侵袭。20微克/毫升的吲哚美辛完全抑制了亚油酸的刺激活性，表明这些脂肪酸的作用是通过类花生酸生物合成介导的。
