Pohl U, Wagner K, de Wit C
Institute of Physiology, Med. Univ. Lübeck, Germany.
Eur Heart J. 1993 Nov;14 Suppl I:93-8.
Since the development of specific NO-synthase inhibitors it has become possible to study the role of NO in the control of local blood flow and tissue oxygenation. Inhibition of NO-synthase induces hypertension and abnormal vasoconstriction, as well as tissue hypoxia and impaired adaptation of blood flow to increased tissue oxygen demands. These functional alterations are similar to those observed in a number of cardiovascular diseases. The present evidence that impaired endothelial function is a pathogenetic factor in the development of cardiovascular diseases is briefly reviewed.
自从特异性一氧化氮合酶抑制剂被研发出来后，研究一氧化氮在局部血流控制和组织氧合中的作用就成为了可能。抑制一氧化氮合酶会诱发高血压和异常血管收缩，以及组织缺氧和血流对增加的组织氧需求的适应性受损。这些功能改变与在一些心血管疾病中观察到的情况相似。本文简要综述了目前关于内皮功能受损是心血管疾病发生发展中的一个致病因素的证据。
