Wei G, Oliver B, Pauli D, Mahowald A P
Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106-4901.
Dev Biol. 1994 Jan;161(1):318-20. doi: 10.1006/dbio.1994.1032.
Mutations at a few genetic loci in Drosophila cause ovarian tumors with hundreds of poorly differentiated germ cells. We examined several of these mutants to test the hypothesis that such ovarian tumors contain sex-transformed cells. By testing for expression of male germline traits, we determined that partial germline sex transformation occurs in otu, snf, Sxlfs, and bam ovarian tumors. Thus these genes are likely to be required for proper establishment of germline sexual identity.
果蝇中少数基因座的突变会导致卵巢肿瘤，其中含有数百个分化不良的生殖细胞。我们研究了其中几个突变体，以检验这样的假设，即此类卵巢肿瘤含有性转变细胞。通过检测雄性生殖系性状的表达，我们确定在otu、snf、Sxlfs和bam卵巢肿瘤中发生了部分生殖系性转变。因此，这些基因可能是正确建立生殖系性别特征所必需的。
