Stefanović V, Bogićević M, Mitić M
Institute of Nephrology and Hemodialysis, Faculty of Medicine, Nis, Yugoslavia.
Int J Artif Organs. 1993 Sep;16(9):659-61.
Increased serum myoglobin levels were previously found in patients with chronic renal failure. In this report we have studied the effects of dialysis on myoglobin elimination in patients on CAPD, IPD, cuprophan and polyacrylonitrile (PAN) membrane hemodialysis. Peritoneal dialysis removed a significant amount of myoglobin, CAPD 480 +/- 65 micrograms/day, IPD 270 +/- 25 micrograms/12 h treatment, while with cuprophan dialysis none, and with PAN dialysis only an insignificant amount of myoglobin. The serum myoglobin levels were 250 +/- 18 and 264 +/- 14 micrograms/l on cuprophan and a 3 month dialysis on PAN membrane, respectively. Markedly increased serum levels were also found in CAPD and IPD patients on peritoneal dialysis, 227 +/- 25 and 286 +/- 32 micrograms/l respectively. This study has shown that there is an increased serum myoglobin concentration in end-stage kidney disease patients on dialysis. Although peritoneal membrane is permeable to myoglobin, a relatively small amount is removed, and the serum level in CAPD and IPD patients was not significantly different from the serum myoglobin concentration in hemodialysis patients. Furthermore myoglobin could not be removed by hemodialysis membrane and an analysis of its important extrarenal catabolism level points were analyzed.
先前在慢性肾衰竭患者中发现血清肌红蛋白水平升高。在本报告中，我们研究了透析对接受持续性非卧床腹膜透析（CAPD）、间歇性腹膜透析（IPD）、铜仿膜和聚丙烯腈（PAN）膜血液透析患者肌红蛋白清除的影响。腹膜透析可清除大量肌红蛋白，CAPD为480±65微克/天，IPD为270±25微克/12小时治疗量，而铜仿膜透析无清除，PAN膜透析仅清除少量肌红蛋白。接受铜仿膜透析和PAN膜3个月透析的患者血清肌红蛋白水平分别为250±18微克/升和264±14微克/升。接受腹膜透析的CAPD和IPD患者血清水平也显著升高，分别为227±25微克/升和286±32微克/升。本研究表明，接受透析的终末期肾病患者血清肌红蛋白浓度升高。虽然腹膜对肌红蛋白具有通透性，但清除量相对较少，CAPD和IPD患者的血清水平与血液透析患者的血清肌红蛋白浓度无显著差异。此外，血液透析膜不能清除肌红蛋白，并对其重要的肾外分解代谢水平点进行了分析。
