Kase M, Suzuki Y, Nagata R, Chin S, Fukushima K
Department of Ophthalmology, Teine Keijin-kai Hospital, Sapporo, Japan.
Jpn J Ophthalmol. 1993;37(3):301-9.
The visually elicited saccades and smooth pursuits of a 24-year-old man with bilateral internuclear ophthalmoplegia were recorded with an infrared limbus reflection technique. Although the amplitude-peak velocity relationship of saccades appeared to be normal, all the upward saccades were hypermetric and were followed by postsaccadic exponential drifts. The time constant of the postsaccadic exponential drifts was 248 +/- 19.5 ms (mean +/- SD). Upward pursuit eye movements were also severely disturbed, and only movements with a short duration (mean 113.8 ms) and low gain (mean 0.51) were frequently observed. Thus, the transformation of a pulse velocity signal for saccades and of a step velocity signal for smooth pursuits into step and ramp position commands, respectively, was almost completely lost for upward eye movements in this patient because of bilateral lesions of the medial longitudinal fasciculus.
采用红外角膜缘反射技术记录了一名患有双侧核间性眼肌麻痹的24岁男性的视诱发扫视和平稳跟踪。虽然扫视的幅度-峰值速度关系似乎正常，但所有向上扫视均为超距性，随后伴有扫视后指数漂移。扫视后指数漂移的时间常数为248±19.5毫秒（平均值±标准差）。向上跟踪眼球运动也受到严重干扰，仅频繁观察到持续时间短（平均113.8毫秒）且增益低（平均0.51）的运动。因此，由于内侧纵束的双侧病变，该患者向上眼球运动时，分别将扫视的脉冲速度信号和平稳跟踪的阶跃速度信号转换为阶跃和斜坡位置指令的功能几乎完全丧失。
