Brown P
MRC Human Movement and Balance Unit, Institute of Neurology, London, England.
J Neuroophthalmol. 1998 Mar;18(1):36-9.
The eyelid-mounted accelerometer can pick up the acceleration waveform of the eye during horizontal eye movements. The acceleration profile comprises high-amplitude pulsatile activity in the saccade and changes in the level of background ocular microtremor related to eye position. Adducting saccades of 20 degrees were recorded in eight patients with partial internuclear ophthalmoplegias caused by multiple sclerosis and in eight age-matched healthy subjects. The initial pulse of acceleration activity was reduced by 85% in the patients. In the worst-affected cases, adducting saccades were associated only with an increase in the level of background ocular microtremor in the acceleration trace. The results confirm the hypothesis that an internuclear ophthalmoplegia is due to the loss of the pulse signal to ocular motor neurons, with preservation of the step signal in an adducting saccade.
安装在眼睑上的加速度计能够在眼球水平运动期间采集眼球的加速度波形。加速度曲线包括扫视期间的高振幅搏动性活动以及与眼位相关的背景性眼球微震颤水平的变化。记录了8例由多发性硬化症导致的部分核间性眼肌麻痹患者以及8例年龄匹配的健康受试者的20度内收扫视。患者的加速度活动初始脉冲降低了85%。在受影响最严重的病例中，内收扫视仅与加速度轨迹中背景性眼球微震颤水平的增加相关。这些结果证实了以下假设，即核间性眼肌麻痹是由于向眼球运动神经元的脉冲信号丧失，而内收扫视中的阶跃信号得以保留。
