Doslak M J, Kline L B, Dell'Osso L F, Daroff R B
Invest Ophthalmol Vis Sci. 1980 Dec;19(12):1506-11.
We studied refixational eye movements of a patient during the gradual resolution of an internuclear ophthalmoplegia (secondary to head trauma) in an attempt to determine the relative contributions of both medial longitudinal fasciculus (MLF) recovery and secondary central plastic changes. Adduction-refixational eye movements in the affected eye consisted of an initial fast (saccadic) portion followed by a slow drift toward the new intended eye position. The fast and slow components of the movements reflected, respectively, the pulse and step increases in neural innervation. Shortly after the traumatic insult, the affected eye exhibited low adduction gain (pulse gain 0.34; step gain 0.37) and slow saccades with peak velocities of 55% and durations of 278%, normalized for achieved, rather than intended, amplitudes. Several months later the pulse and step gains, peak velocities, and durations of the saccades improved to 0.81, 0.92, 87%, and 145%, respectively. The increased gains and faster velocity were accomplished by increases in the firing frequency of the pulse and step, reflecting recovery of MLF axons, rather than saccadic system plasticity, which would have resulted in increased duration of the saccadic pulse.
我们研究了一名患者在核间性眼肌麻痹（继发于头部外伤）逐渐恢复过程中的修复性眼球运动，以确定内侧纵束（MLF）恢复和继发性中枢可塑性变化的相对作用。患眼的内收修复性眼球运动包括一个初始快速（扫视）部分，随后是缓慢向新的预期眼位漂移。运动的快速和缓慢成分分别反映了神经支配的脉冲式和阶梯式增加。外伤后不久，患眼内收增益较低（脉冲增益0.34；阶梯增益0.37），扫视缓慢，峰值速度为55%，持续时间为278%，以达到的而非预期的幅度进行归一化。几个月后，扫视的脉冲和阶梯增益、峰值速度以及持续时间分别提高到0.81、0.92、87%和145%。增益增加和速度加快是通过脉冲和阶梯放电频率的增加实现的，这反映了MLF轴突的恢复，而不是扫视系统的可塑性，扫视系统可塑性会导致扫视脉冲持续时间增加。
