Taketoshi M, Kitada K, Yakushiji T, Inoue M
Department of Preventive Dentistry, Kagoshima University Dental School, Japan.
Microbios. 1993;76(307):115-29.
Of the 29 'Streptococcus milleri' strains tested, all thirteen Streptococcus intermedius (DNA homology group 2) strains but none of the thirteen Streptococcus anginosus (group 1) strains produced beta-N-acetylglucosaminidase, beta-N-acetylgalactosaminidase, alpha-N-acetylneuraminidase, beta-galactosidase, alpha-glucosidase, and hyaluronidase. The three Streptococcus constellatus (group 3) strains produced only the latter two. Glycosidase production divided 274 clinical isolates into 103 S. anginosus, 101 S. intermedius, and 70 S. constellatus strains. Generally, strains of S. anginosus and S. intermedius were non-beta-haemolytic. API II and biotype Ia (lactose positive), but the former contained almost all API III strains and belonged to Lancefield group A/serotype a (A/a), -/b, C/c, -/d, -/e, F/f or G/k, and the latter included most of biotype IId (lactose negative) and serovar -/g, -/h, -/i or -/j. S constellatus strains were beta-, alpha- or gamma-haemolytic, of API I or II but mostly biotype Ib (lactose negative), and of F/- or -/b. S. intermedius was a major member of the oral isolates. Non-oral isolates were virtually all S. anginosus (mainly urogenital isolates) or S. constellatus (the other systemic isolates).
在检测的29株“米勒链球菌”菌株中，所有13株中间型链球菌（DNA同源群2）菌株均产生β-N-乙酰葡糖胺酶、β-N-乙酰半乳糖胺酶、α-N-乙酰神经氨酸酶、β-半乳糖苷酶、α-葡萄糖苷酶和透明质酸酶，而13株咽峡炎链球菌（群1）菌株均未产生。3株星座链球菌（群3）菌株仅产生后两种酶。糖苷酶的产生将274株临床分离株分为103株咽峡炎链球菌、101株中间型链球菌和70株星座链球菌。一般来说，咽峡炎链球菌和中间型链球菌菌株不产生β溶血。API II和生物型Ia（乳糖阳性），但前者几乎包含所有API III菌株，属于兰斯菲尔德A群/血清型a（A/a）、-/b、C/c、-/d、-/e、F/f或G/k，后者包括大多数生物型IId（乳糖阴性）和血清型-/g、-/h-/i或-/j。星座链球菌菌株为β溶血、α溶血或γ溶血，属于API I或II，但大多为生物型Ib（乳糖阴性），属于F/-或-/b。中间型链球菌是口腔分离株的主要成员。非口腔分离株几乎均为咽峡炎链球菌（主要是泌尿生殖道分离株）或星座链球菌（其他全身感染分离株）。
