Savula M M, Kravchenko N S, Poznanskiĭ A I
Probl Tuberk. 1993(5):18-20.
The trial included 155 patients with destructive pulmonary tuberculosis: 60 on conventional antibacterial therapy (isoniazid, rifampicin, streptomycin), 95 on intensive chemotherapy (isoniazid, rifampicin, streptomycin, pirazinamid or ethambutol, vitamins for initial 2-3 months). 69 patients from the latter group received adjuvant antioxidants (tocopherol acetate or galascorbin) in combination with one of the antihypoxants (piracetam, calcii pangamas, piriditol). The intensive chemotherapy promoted a decrease in duration of bacterial discharge, destruction discontimation, cavernous healing, reduced incidence rates of side effects. Metabolic processes characterizing lipid peroxidation and redox improved.
该试验纳入了155例毁损型肺结核患者：60例接受传统抗菌治疗（异烟肼、利福平、链霉素），95例接受强化化疗（异烟肼、利福平、链霉素、吡嗪酰胺或乙胺丁醇，最初2 - 3个月补充维生素）。后一组中的69例患者接受了佐剂抗氧化剂（醋酸生育酚或维生素C）与一种抗缺氧剂（吡拉西坦、潘氨酸钙、吡啶硫醇）联合治疗。强化化疗使细菌排菌持续时间缩短、破坏停止、空洞愈合，副作用发生率降低。脂质过氧化和氧化还原反应相关的代谢过程得到改善。
