Sozinov V A, Metelitsina I P, Plotnikova E K, Sinitsa A I, Borisova M I
Probl Tuberk. 1993(5):44-7.
The studies of the effects produced by M. tuberculosis various strains on the activity of lysosomal enzymes in peritoneal mouse macrophages demonstrated multidirectional influence of the bacilli. Non-sedimentary activity rose in matrical enzymes indicating lysosomal membranes instability due to M. tuberculosis infection followed by hydrolase activation and hydrolases escape into the cytosol. An inhibiting action of pathogenic mycobacteria on lysosomal proteases is suggested.
关于结核分枝杆菌不同菌株对小鼠腹腔巨噬细胞溶酶体酶活性影响的研究表明，这些杆菌具有多向性影响。基质酶的非沉积活性升高，表明由于结核分枝杆菌感染导致溶酶体膜不稳定，随后水解酶被激活并逸出到细胞质中。提示致病性分枝杆菌对溶酶体蛋白酶有抑制作用。
