Sagvolden T, Pettersen M B, Larsen M C
Department of Neurophysiology, University of Oslo, Norway.
Physiol Behav. 1993 Dec;54(6):1047-55. doi: 10.1016/0031-9384(93)90323-8.
Childhood hyperkinesis or attention-deficit hyperactivity disorder (ADHD) is a behavior disorder of which the main symptoms are attention problems and hyperactivity. The main objective of the present study was to investigate whether the spontaneously hypertensive rat (SHR) strain is a useful animal model of ADHD. Five different rat strains were tested: SHR, Wistar-Kyoto (WKY), Wistar, Sprague-Dawley (SPRD), and PVG (hooded) rats. The protocol consisted of three different test procedures: 1) A 7.5-min free-exploration open-field test (home cage accessible), where the SHR was less active than Wistar and SPRD but more active than WKY; SHR showed longer latencies to leave the home cage than both Wistar and SPRD rats, spending less time in the field, ambulating and rearing less than Wistar and SPRD but more than WKY. Within session, the SHR tended to be more active at the end of the session than at the start, while the opposite tended to be the case in the other groups. 2) A 7.5-min forced exploration open-field test (home cage not accessible), where the results showed that the SHR is less active than both the Wistar and Sprague-Dawley strains, but more active than PVG and WKY. 3) A two-component multiple schedule of reinforcement with a fixed interval 2 min signalled by houselight on and a 5-min extinction signalled by houselight off. Lever pressing by SHR was markedly different from that of the other four strains, which were quite Except early in the interval, SHR pressed the lever more than any of the other groups.(ABSTRACT TRUNCATED AT 250 WORDS)
儿童多动症或注意力缺陷多动障碍(ADHD)是一种行为障碍,其主要症状为注意力问题和多动。本研究的主要目的是调查自发性高血压大鼠(SHR)品系是否是ADHD的有用动物模型。测试了五种不同的大鼠品系:SHR、Wistar-Kyoto(WKY)、Wistar、Sprague-Dawley(SPRD)和PVG(有帽)大鼠。实验方案包括三种不同的测试程序:1)7.5分钟的自由探索旷场试验(可进入饲养笼),在此试验中,SHR的活动比Wistar和SPRD少,但比WKY多;SHR离开饲养笼的潜伏期比Wistar和SPRD大鼠都长,在旷场内停留的时间较少,走动和竖毛比Wistar和SPRD少,但比WKY多。在试验过程中,SHR在试验结束时比开始时更活跃,而其他组则相反。2)7.5分钟的强迫探索旷场试验(不可进入饲养笼),结果表明SHR比Wistar和Sprague-Dawley品系的活动少,但比PVG和WKY多。3)一种双成分多重强化程序,亮灯2分钟为固定间隔强化,熄灯5分钟为消退期。SHR的杠杆按压与其他四种品系明显不同,其他四种品系相当相似。除了在间隔早期,SHR按压杠杆的次数比其他任何组都多。(摘要截短于250字)