Roa I, Villaseca M, Wistuba I, Araya J C, De Aretxabala X
Unidad de Anatomía Patológica-Citopatologia, Facultad de Medicina, Universidad de La Frontera, Hospital Regional de Temuco, Santiago, Chile.
Rev Med Chil. 1993 Aug;121(8):897-902.
The cytofluorometric determination of ADN content in tumoral cells from 33 tumors is reported. Twenty five epithelial (2 benign and 23 malignant) and 8 non epithelial tumors (1 benign and 7 malignant) were studied. All the benign tumors had a normal ADN content (2c); on the other hand, 65% of malignant tumors had an abnormal ADN content. All non epithelial malignant tumors were aneuploid. Among aneuploid tissues, epithelial tumors were frequently tetraploid (4c) and non epithelial tumors were frequently polyploid 6c, 8c, 12c). It is concluded that this technique gives valuable information about the biological characteristics of tumoral cells and that its results could be incorporated to the routine anatomopathological study of tumoral lesions.
本文报道了用细胞荧光测定法对33例肿瘤的肿瘤细胞中DNA含量的测定结果。研究了25例上皮性肿瘤（2例良性和23例恶性）和8例非上皮性肿瘤（1例良性和7例恶性）。所有良性肿瘤的DNA含量均正常（2c）；另一方面，65%的恶性肿瘤DNA含量异常。所有非上皮性恶性肿瘤均为非整倍体。在非整倍体组织中，上皮性肿瘤常为四倍体（4c），而非上皮性肿瘤常为多倍体（6c、8c、12c）。结论是，该技术可提供有关肿瘤细胞生物学特性的有价值信息，其结果可纳入肿瘤病变的常规解剖病理学研究。
