Venables K M, Graneek B J, Taylor A J
Department of Occupational and Environmental Medicine, National Heart and Lung Institute (University of London), Brompton Hospital, England.
Scand J Work Environ Health. 1993 Oct;19(5):342-5. doi: 10.5271/sjweh.1465.
Although poorly reproducible spirometric tests, "test failures," are associated with respiratory morbidity, it is not clear what causes them. Bronchial responsiveness was examined in relation to test failure for forced expiratory volume in 1 s (FEV1.0) (1979 definition of the American Thoracic Society) in 249 bakers, 165 chemical industry workers, and 204 office workers. The first two groups were studied by the same methods and were combined. Test failure was observed in 4%, and for 38% the provocative dose of inhaled methacholine causing a 20% fall in FEV1.0 relative to FEV1.0 after the inhalation of normal saline (PD20) was < or = 120 mumol (7% with a PD20 of < or = 8 mumol). Test failure was not related to the level of PD20. Of the office workers, 3% had test failure, 11% a PD20 of < or = 8 mumol of histamine, and no significant relation was observed. The study does not exclude the possibility that bronchial responsiveness might be related to test failure in patients with airway disease or that a clearer relation might be demonstrable in a larger study, but it does suggest that it is not a major determinant of test failure.
尽管肺量计测试结果重复性差（“测试失败”）与呼吸道发病率相关，但尚不清楚其原因。对249名面包师、165名化工行业工人和204名办公室职员，就一秒用力呼气量（FEV1.0，美国胸科学会1979年定义）测试失败情况进行了支气管反应性检查。前两组采用相同方法进行研究并合并。观察到4%的测试失败，38%的人吸入组胺后FEV1.0较吸入生理盐水后FEV1.0下降20%时的激发剂量（PD20）≤120 μmol（7%的人PD20≤8 μmol）。测试失败与PD20水平无关。办公室职员中，3%测试失败，11%组胺激发剂量（PD20）≤8 μmol，未观察到显著相关性。该研究并未排除支气管反应性可能与气道疾病患者测试失败有关，或在更大规模研究中可能显示出更明确相关性的可能性，但确实表明支气管反应性并非测试失败的主要决定因素。
