Shabalin A V, Vergeĭchik T Kh
Sud Med Ekspert. 1993 Oct-Dec;36(4):29-30.
Optimal conditions for carbamazepine isolation from cadaveric liver have been determined. The authors recommend the material infusion with alcohol acidified with sulfuric acid to pH 1 three times for an hour. Conditions for measuring the isolated drug quantity have been developed. Fluorescent polarization immunoanalysis in the TDX system has been used for the first time. Carbamazepine detection limit for 50 g of the liver was found to be 2.5 x 10(-7) g.
已确定从尸体肝脏中分离卡马西平的最佳条件。作者建议用硫酸酸化至pH 1的酒精对材料进行三次一小时的灌注。已制定了测量分离药物量的条件。首次在TDX系统中使用荧光偏振免疫分析法。发现50克肝脏中卡马西平的检测限为2.5×10(-7)克。