Nitsche A, Tejeda A, Gallo J E, Chianello M
Unidad Reumatología, Policlinica Bancaria, Bs As, Argentina.
Acta Gastroenterol Latinoam. 1993;23(3):151-8.
Idiopathic inflammatory bowel disease include basically two disorders: ulcerative colitis and Crohn's disease. Both diseases are chronic and of unknown etiology and extraintestinal manifestations are seen in a high number of these patients. We studied 18 patients (7 female, 11 male) with previous diagnosis of inflammatory bowel disease (14 ulcerative colitis, 2 Crohn's disease, 1 pancolitis, 1 ulcerative proctitis) in order to search for extraintestinal manifestations with emphasis on osteoarticular and ocular involvement. The mean age at the time of diagnosis of the inflammatory bowel disease was 44 years (range 20 to 71 years). Mean time duration of the inflammatory bowel disease was 7 years (range 1 to 24 years) and of the articular manifestations 3.2 years (range 1 to 8 years). The osteoarticular manifestations developed after the diagnosis of the bowel disease in all but one patient (simultaneously) 17/18 patients had artralgias, 7/18 lumbalgia, 3/18 talalgia, 1/18 knee arthritis. (table I) Only six of the 17 patients with orteoarticular involvement has simultaneous activity of the underlying bowel disease. All the 18 patients were taking 2 g/day of sulfasalazine. Radiographic screening in all patients revealed sacroiliitis in 10. (table II) Of the 10 radiographic sacroiliitis 4 were grade I (confirmed by technetium phosphate scans, 2 were grade II and 4 grade III-IV. Three of the ten patients with radiographic sacroiliitis were asymptomatic (table II). Axial computed tomography was performed done in two patients: a) in one case to exclude osteitis condensens ilii, and b) in the other case to exclude septic arthritis. The severity of the sacroiliac damage was related with a longer duration of the inflammatory bowel disease.(ABSTRACT TRUNCATED AT 250 WORDS)
溃疡性结肠炎和克罗恩病。这两种疾病均为慢性且病因不明,大量此类患者会出现肠外表现。我们研究了18例先前诊断为炎症性肠病的患者(7例女性,11例男性)(14例溃疡性结肠炎、2例克罗恩病、1例全结肠炎、1例溃疡性直肠炎),以寻找肠外表现,重点关注骨关节和眼部受累情况。炎症性肠病诊断时的平均年龄为44岁(范围20至71岁)。炎症性肠病的平均病程为7年(范围1至24年),关节表现的平均病程为3.2年(范围1至8年)。除1例患者外(同时出现),所有患者的骨关节表现均在肠道疾病诊断后出现。17/18例患者有关节痛,7/18例有腰痛,3/18例有足跟痛,1/18例有膝关节炎。(表I)17例有骨关节受累的患者中只有6例同时存在基础肠道疾病活动。所有18例患者均服用每日2克柳氮磺胺吡啶。所有患者的影像学筛查显示10例有骶髂关节炎。(表II)在10例影像学骶髂关节炎中,4例为I级(经磷酸锝扫描证实),2例为II级,4例为III - IV级。10例有影像学骶髂关节炎的患者中有3例无症状。(表II)对2例患者进行了轴向计算机断层扫描:a)1例用于排除致密性髂骨炎,b)另1例用于排除化脓性关节炎。骶髂关节损伤的严重程度与炎症性肠病的病程较长有关。(摘要截短至250字)