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Myeloperoxidase binds to vascular endothelial cells, is recognized by ANCA and can enhance complement dependent cytotoxicity.

作者信息

Savage C O, Gaskin G, Pusey C D, Pearson J D

机构信息

Vascular Biology Section, Clinical Research Centre, Harrow, U.K.

出版信息

Adv Exp Med Biol. 1993;336:121-3. doi: 10.1007/978-1-4757-9182-2_20.

DOI:10.1007/978-1-4757-9182-2_20
PMID:8296599
Abstract

Myeloperoxidase (MPO) and proteinase-3 (Pr-3) can bind to vascular endothelial cells (EC) and are available for recognition by autoantibodies present in P-ANCA or C-ANCA containing sera, respectively. The bound MPO also retains its enzymic functions and effectively interacts with hydrogen peroxide to mediate detachment of endothelial cells from their substratum. EC bound MPO-anti-MPO complexes can contribute to the complement-dependent EC injury demonstrated by some P-ANCA sera.

摘要

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