Qasim F J, Mathieson P W, Thiru S, Oliveira D B, Lockwood C M
Department of Medicine, University of Cambridge, England.
Adv Exp Med Biol. 1993;336:133-7. doi: 10.1007/978-1-4757-9182-2_23.
The demonstration of vasculitis and anti-myeloperoxidase antibodies in the mercuric chloride treated Brown Norway rat provides a useful, though limited, animal model of systemic vasculitis. We describe some preliminary experiments on the effect of transfer of serum from mercuric chloride treated rats and of two forms of immunotherapy: intravenous immunoglobulin and an anti-CD4 antibody. Transfer of serum did not lead to tissue injury and neither of the two forms of therapy proved beneficial in this model.
在经氯化汞处理的Brown Norway大鼠中证实了血管炎和抗髓过氧化物酶抗体，这提供了一个有用但有局限性的系统性血管炎动物模型。我们描述了一些关于转移经氯化汞处理大鼠的血清以及两种免疫疗法（静脉注射免疫球蛋白和抗CD4抗体）效果的初步实验。血清转移并未导致组织损伤，并且在该模型中这两种疗法均未显示出有益效果。
