肝胆疾病患者中抗中性粒细胞胞浆抗体（ANCA）的检测及其与其他自身抗体的关联。

Detection of antineutrophil cytoplasmatic antibodies (ANCA) and their association with other autoantibodies in patients with hepatobiliary disorders.

作者信息

Gruber R, Brockmeyer C, Hoechtlen-Vollmar W, Bittlingmaier R, Trimborn S, Riethmüller G

机构信息

Institute for Immunology, University of Munich, Germany.

出版信息

Adv Exp Med Biol. 1993;336:539-44. doi: 10.1007/978-1-4757-9182-2_98.

DOI:10.1007/978-1-4757-9182-2_98

PMID:8296672

Abstract

Sera from 35 out of 655 patients with suspected or confirmed hepatobiliary diseases were positive for anti-neutrophil antibodies with a perinuclear staining pattern (p-ANCA). Nineteen of these sera did not react with myeloperoxidase (MPO), Cathepsin G or Elastase, the three proposed antigens of p-ANCAs. No distinct antigen for these sera could be characterized by western blot techniques with fractionated granulocyte proteins.

摘要

655例疑似或确诊肝胆疾病患者中，35例患者的血清抗中性粒细胞抗体呈核周染色模式（p-ANCA）阳性。其中19份血清不与髓过氧化物酶（MPO）、组织蛋白酶G或弹性蛋白酶发生反应，这三种物质是p-ANCA的三种假定抗原。通过粒细胞蛋白分级分离的蛋白质印迹技术，无法鉴定出这些血清的特异性抗原。