自身免疫性肝病中的抗中性粒细胞胞浆抗体（ANCA）
Anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune liver disease.
作者信息
Mulder A H, Horst G, Haagsma E B, Kleibeuker J H, Kallenberg C G
机构信息
Department of Clinical Immunology, University Hospital Groningen, The Netherlands.
出版信息
Adv Exp Med Biol. 1993;336:545-9. doi: 10.1007/978-1-4757-9182-2_99.
ANCA were detected in 67% of sera from patients with primary sclerosing cholangitis (n = 15), in 83% of sera from patients with autoimmune chronic active hepatitis (n = 18) and in 35% of sera from patients with primary biliary cirrhosis (n = 20). ANCA were not detected in non-autoimmune chronic liver diseases. Characterization studies of the antigens involved showed that ANCA in autoimmune liver disease are not directed against myeloperoxidase (mpo), proteinase 3 (pr3) or elastase (hle), but the ANCA in autoimmune liver disease show reactivity with lactoferrin, a 67/66 kD protein combination or a 63/54 kD protein combination on Western Blots.
在原发性硬化性胆管炎患者（n = 15）的67%血清中检测到抗中性粒细胞胞浆抗体（ANCA），在自身免疫性慢性活动性肝炎患者（n = 18）的83%血清中以及在原发性胆汁性肝硬化患者（n = 20）的35%血清中检测到ANCA。在非自身免疫性慢性肝病患者中未检测到ANCA。对相关抗原的特性研究表明，自身免疫性肝病中的ANCA并非针对髓过氧化物酶（mpo）、蛋白酶3（pr3）或弹性蛋白酶（hle），但自身免疫性肝病中的ANCA在蛋白质印迹法中与乳铁蛋白、一种67/66 kD蛋白组合或一种63/54 kD蛋白组合有反应性。
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