van Beusekom H M, Serruys P W, Post J C, Verdouw P D, van der Giessen W J
Department of Cardiology, Erasmus University Rotterdam, The Netherlands.
Am Heart J. 1994 Feb;127(2):273-81. doi: 10.1016/0002-8703(94)90113-9.
In a model of early and aggressive vein graft stenosis in pigs, an intervention was performed with a single stent (n = 12 grafts), multiple stents (n = 6), or balloon angioplasty (n = 6), while grafts with mild stenoses were left untreated (n = 8). Four weeks after intervention, angiography showed that grafts with single stents, balloon angioplasty, or untreated grafts had patency rates of 92%, 83%, and 83%, respectively. Grafts receiving multiple stents, however, showed only a 17% patency rate (p < 0.05). Balloon dilatation or placement of a single stent improved the angiographic minimal diameter by 0.6 +/- 0.2 and 0.8 +/- 0.3 mm, respectively, over the short term, but this gain was lost during the follow-up period. Multiple stents showed a similar gain (0.5 +/- 0.2 mm) but more loss occurred during the follow-up period (2.4 +/- 0.2 mm). Histology revealed no significant differences between the treatment groups except for the prolonged presence of thrombus remnants in association with the stent wires. In conclusion, single stents and balloon angioplasty show good patency in early saphenous vein graft narrowing but multiple stents show a high occlusion rate.
在猪早期侵袭性静脉移植物狭窄模型中，对12个移植物进行单支架干预、6个移植物进行多支架干预、6个移植物进行球囊血管成形术，而轻度狭窄的移植物不进行治疗（8个）。干预四周后，血管造影显示单支架移植物、球囊血管成形术移植物或未治疗移植物的通畅率分别为92%、83%和83%。然而，接受多支架的移植物通畅率仅为17%（p<0.05）。短期内，球囊扩张或单支架置入分别使血管造影最小直径增加了0.6±0.2和0.8±0.3毫米，但在随访期间这一增加消失。多支架显示出类似的增加（0.5±0.2毫米），但在随访期间有更多减少（2.4±0.2毫米）。组织学显示，各治疗组之间无显著差异，但与支架丝相关的血栓残余物存在时间延长。总之，单支架和球囊血管成形术在早期大隐静脉移植物狭窄中显示出良好的通畅性，但多支架显示出高闭塞率。
