注意缺陷多动障碍儿童的5-羟色胺能功能：与后期反社会人格障碍的关系。
Serotonergic function in children with attention-deficit hyperactivity disorder: relationship to later antisocial personality disorder.
作者信息
Flory Janine D, Newcorn Jeffrey H, Miller Carlin, Harty Seth, Halperin Jeffrey M
机构信息
Department of Psychology, Queens College, City University of New York, 65-30 Kissena Boulevard, SB-318 Flushing, NY 11367, USA.
出版信息
Br J Psychiatry. 2007 May;190:410-4. doi: 10.1192/bjp.bp.106.027847.
BACKGROUND
Impulsive aggression in adulthood is associated with disturbances in serotonergic function. In contrast, research examining this association in childhood has yielded inconsistent results.
AIMS
The current study examined the prospective relationship between serotonergic function measured in childhood and the later emergence of antisocial personality disorder.
METHOD
Hormonal response to fenfluramine, an index of serotonergic function, was assessed in 58 children with attention-deficit hyperactivity disorder between 1990 and 1997 when they were aged 7-11 years. Approximately 9 years later these individuals were evaluated for antisocial personality disorder.
RESULTS
Lower serotonergic responsivity assessed in childhood predicted the development of antisocial personality disorder (t (56)=2.25, P=0.028).
CONCLUSIONS
These results provide a critical link between the child and adult literature on the covariation of impulsive aggression and serotonergic function and suggest a potential explanation for inconsistencies in the childhood literature.
背景
成年期的冲动攻击性与血清素能功能紊乱有关。相比之下，对儿童期这种关联的研究结果并不一致。
目的
本研究考察了儿童期测量的血清素能功能与反社会人格障碍后期出现之间的前瞻性关系。
方法
1990年至1997年期间，对58名患有注意力缺陷多动障碍的儿童（年龄在7至11岁之间）进行了氟苯丙胺的激素反应评估，这是血清素能功能的一个指标。大约9年后，对这些个体进行反社会人格障碍评估。
结果
儿童期评估的较低血清素能反应性预测了反社会人格障碍的发展（t(56)=2.25，P=0.028）。
结论
这些结果在关于冲动攻击性和血清素能功能共变的儿童和成人文献之间建立了关键联系，并为儿童文献中的不一致性提供了一个潜在解释。
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