破坏性行为障碍的异质性 - 对神经生物学研究和治疗的启示。
The heterogeneity of disruptive behavior disorders - implications for neurobiological research and treatment.
机构信息
Department of Child and Adolescent Psychiatry, Johann Wolfgang Goethe University Frankfurt am Main, Germany.
出版信息
Front Psychiatry. 2010 Oct 11;1:21. doi: 10.3389/fpsyt.2010.00021. eCollection 2010.
Abstract
Disruptive behavior disorders (DBDs) are reflected by a great variety of symptoms ranging from impulsive-hot-tempered quarrels to purposeful and goal-directed acts of cruelty. A growing body of data indicates that there are neurobiological factors that increase the risk for developing DBDs. In this review, we give a broad overview of recent studies investigating physiological, neural, genetic factors, and specific neurotransmitter systems. We also discuss the impact of psychosocial risk and consider the effects of gene-environment interactions. Due to the heterogeneity of DBDs, it is concluded that specific subtypes of disruptive behavior should be considered both in terms their biological basis and in regard to specific treatment needs.
摘要
破坏性行为障碍（DBD）表现为多种症状，从冲动易怒的争吵到有目的、有目标的残忍行为。越来越多的数据表明，存在一些神经生物学因素会增加患上 DBD 的风险。在这篇综述中，我们广泛概述了最近研究中调查生理、神经、遗传因素和特定神经递质系统的研究。我们还讨论了心理社会风险的影响，并考虑了基因-环境相互作用的影响。由于 DBD 的异质性，我们得出结论，破坏性行为的特定亚型应从其生物学基础和特定治疗需求两方面来考虑。
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