Vogt T, Pope C, Mullooly J, Hollis J
Kaiser Permanente Center for Health Research, Portland, Ore. 97227.
Am J Public Health. 1994 Feb;84(2):227-31. doi: 10.2105/ajph.84.2.227.
This study sought to relate preexisting depression, worries, affect balance, and mental health symptoms to subsequent risk of morbidity and mortality.
A random sample of members of a health maintenance organization were interviewed at home in a 1970/71 survey. Baseline psychological measures from that survey were then related to 15-year mortality and first incidence of cancer, heart disease, hypertension, stroke, functional gastrointestinal disease, and hyperimmune diseases.
Baseline depression and the Langner Mental Health Index predicted incidence of functional gastrointestinal and hyperimmune diseases. The relationship of the Langner index to hyperimmune diseases was particularly strong; mortality, cancer, heart disease, hypertension, and stroke incidence were not related to that index. Except for affect balance, which was worst in the elderly, indications of psychological dysfunction were strongest in the young.
Psychological indices detected increased risk for functional gastrointestinal and hyperimmune diseases but were not related to mortality risk. Further research is needed to disaggregate relationships of the specific conditions that were included in the hyperimmune group. Functional gastrointestinal disease might be preventable with early attention to depressed persons and to those scoring high on the Langner index.
本研究旨在探讨既往存在的抑郁、担忧、情感平衡和心理健康症状与后续发病和死亡风险之间的关系。
在1970/71年的一项调查中,对一家健康维护组织的成员进行了随机抽样,并在家中进行访谈。该调查的基线心理测量指标随后与15年死亡率以及癌症、心脏病、高血压、中风、功能性胃肠疾病和高免疫疾病的首次发病情况相关联。
基线抑郁和朗纳心理健康指数可预测功能性胃肠疾病和高免疫疾病的发病率。朗纳指数与高免疫疾病的关系尤为密切;死亡率、癌症、心脏病、高血压和中风发病率与该指数无关。除了情感平衡在老年人中最差外,心理功能障碍的指标在年轻人中最为明显。
心理指标检测到功能性胃肠疾病和高免疫疾病的风险增加,但与死亡风险无关。需要进一步研究以区分高免疫组中所包含的特定疾病之间的关系。早期关注抑郁症患者和朗纳指数得分高的人,功能性胃肠疾病可能是可预防的。