黄曲霉毒素B1代谢的种属差异。

Species differences in the metabolism of aflatoxin B1.

作者信息

Emafo P O

出版信息

Afr J Med Med Sci. 1976 Mar;5(1):55-62.

Abstract

The metabolism of aflatoxin B1 in a number of animals was investigated. Aflatoxin B1 is metabolized relatively more slowly in liver slices of sheep than in the mouse, goat, guinea-pig, rabbit and golden hamster. The rate of metabolism of the toxin by the 10,000 g supernatant is faster than the metabolism by liver slices. This may be as a result of the substrate not penetrating the liver cells readily. Species difference exist in the in vitro metabolism of aflatoxin B1 by hydroxylation and demethylation. The sheep and White Rock cockerel demethylate aflatoxin B1 poorly but the dog and duck do not demethylate the toxin at all. Of the animals studied, the duck, mouse and White Rock cockerel do not produce aflatoxin M1 at all. The sheep and dog produce aflatoxin M1 in comparatively large amounts, while the rat, goat and golden hamster produce aflatoxin M1 in smaller quantities.

摘要

对多种动物体内黄曲霉毒素B1的代谢情况进行了研究。黄曲霉毒素B1在绵羊肝脏切片中的代谢相对比在小鼠、山羊、豚鼠、兔子和金黄仓鼠中要慢。该毒素经10,000g上清液的代谢速率比经肝脏切片的代谢速率要快。这可能是由于底物不易穿透肝细胞所致。黄曲霉毒素B1经羟基化和去甲基化的体外代谢存在种属差异。绵羊和白洛克公鸡对黄曲霉毒素B1的去甲基化能力较差，而狗和鸭则完全不能使该毒素去甲基化。在所研究的动物中，鸭、小鼠和白洛克公鸡根本不产生黄曲霉毒素M1。绵羊和狗产生相对大量的黄曲霉毒素M1，而大鼠、山羊和金黄仓鼠产生的黄曲霉毒素M1量较少。